Santini is an Italian surname. Notable people with the surname include:
André Santini (born 1940), French politician
Bob Santini (born 1932), American former professional basketball player
Brandon Santini (born 1982), American blues harmonica player, singer and songwriter
Chay Santini, Puerto Rican fashion model and actress
Claudio Santini (born 1992), Italian football player
Dalmazio Santini (1923 - 2001), Italian-born U.S. composer
Daniele Santini (born 1992), Italian sprint canoeist.
Didier Santini (born 1968), retired French professional football player
Edna Santini (born 1992), Brazilian rugby sevens player
Fortunato Santini (1777-1861), Italian priest, composer and music collector
Gabriel Santini (born 2000), Italian footballer
Gabriele Santini (1886-1964), Italian conductor
Giovanni Sante Gaspero Santini (1787-1877), Italian astronomer and mathematician
Graziella Santini (born 1960), Sammarinese athlete
Giuseppe Santini (1735-1796), Italian abbot and a mathematician
Inti Muñoz Santini (born 1974), Mexican politician
Ivan Santini (born 1989), Croatian footballer
Jacques Santini, French footballer
James David Santini (1937-2015), United States Representative from Nevada
Jan Santini Aichel (1677-1723), Czech baroque architect of Italian descent
Jorge Santini, Puerto Rican politician, former mayor of San Juan
Krševan Santini (born 1987), Croatian football goalkeeper
Nadia Santini, Italian chef
Nilmaris Santini (1959-2006), Puerto Rican female judoka
Norma Santini (born 1932), Venezuelan fencer
Rinaldo Santini (1914-2013), Italian Christian Democrat politician
Ruggiero Santini (1870-1958), Italian general
Steven Santini (born 1995), American ice hockey defenseman
Seven Santini Brothers, founders of the eponymous moving and storage company
Wellentony Tafua Santini (born 1993), Australian rugby league footballer
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