Sakuma (written: 佐久間) is a Japanese surname. Notable people with the surname include:
Akira Sakuma (佐久間 晃; born 1952), Japanese video game designer
Chie Sakuma (佐久間 千絵; born 1972), Japanese-American retired ice hockey player
Daisuke Sakuma (佐久間 大介; born 1992), Japanese idol, tarento, actor, member of boy band Snow Man
Hanzō Sakuma (佐久間 範造; 1844–1897), Japanese photographer
Katsuhiko Sakuma (佐久間 勝彦; born 1970), Japanese weightlifter
Kumi Sakuma (佐久間 紅美; born 1976), Japanese voice actress
Morimasa Sakuma (佐久間 盛政; 1554-1583), prominent Oda retainer, cousin of Nobumori Sakuma
Morishige Sakuma (佐久間 盛重; died 1560), Japanese samurai who served Oda Nobunaga
Nobumori Sakuma (佐久間 信盛; 1528–1582), retainer of the Oda clan, cousin of Morimasa Sakuma
Rei Sakuma (佐久間 レイ; born 1965), Japanese actress, voice actress, singer, narrator
Rio Sakuma (佐久間 理央; born 1997), Japanese professional footballer
Roy Sakuma (born 1948), Hawaiian ukulele teacher and founder of the Ukulele Festival
Samata Sakuma (佐久間 左馬太; 1844–1915), Imperial Japanese Army general
Satoru Sakuma (佐久間 悟; born 1963), Japanese former football player and manager
Shōzan Sakuma (佐久間 象山; 1811–1864), Japanese politician and scholar of the Edo period
Tatsuya Sakuma (佐久間 達也; born 1974), Japanese former professional drifting driver
Tsutomu Sakuma (佐久間 勉; 1879–1910), Imperial Japanese Navy career naval officer
Yoshiko Sakuma (佐久間 良子; born 1939), Japanese actress
Yui Sakuma (佐久間 由衣; born 1995), Japanese actress and model
Fictional characters
Ryuichi Sakuma, a character in the anime and manga series Gravitation
Kotaro Sakuma, a character in the Uchu Sentai Kyuranger
Sakuma Kichiro, a character in Age of Empires III: The Asian Dynasties campaign and main protagonist of the Japanese campaign
Sakuya Sakuma (佐久間 咲也), a character in A3!
Sakuma Rei and Sakuma Ritsu from Ensemble Stars!
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