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Nicole Rene Glaser (; born June 1, 1984) is an American stand-up comedian and actress. She has had four television stand-up specials, hosted numerous award shows, and performed at numerous televised roasts, gaining significant popularity for her set on The Roast of Tom Brady. Previously, she hosted the television talk show Not Safe with Nikki Glaser, which premiered on Comedy Central in 2016. She starred in the 2022 reality show Welcome Home Nikki Glaser? on E! She hosted the reality TV dating shows Blind Date (2019) on Bravo and FBoy Island (2021–2023) on HBO Max and The CW and its spinoff Lovers and Liars on The CW. She also hosted the 2025 and 2026 Golden Globe Awards, which made her the first solo female host in Golden Globes history.
She has acted in the Amy Schumer comedy films Trainwreck (2015) and I Feel Pretty (2018) and has appeared on shows such as Inside Amy Schumer and A.P. Bio. She has competed in competition shows such as Dancing with the Stars (2018) and The Masked Singer (2022). She has also participated in the roasts of Rob Lowe (2016), Bruce Willis (2018), Alec Baldwin (2019), and the aforementioned roast of Tom Brady (2024). She has received nominations at the Critics' Choice Television Awards, Golden Globe Awards, Grammy Awards, and Primetime Emmy Awards. She was included in the annual Time 100 list of the most influential people in the world in 2026.

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