Mayes is a surname. Notable people with the surname include:
Adrian Mayes (born 1980), American football player
Alan Mayes (born 1953), English footballer
Bernard Mayes (1929–2014), British-American lecturer and author
Clifford Mayes (born 1953), American professor of education
Clyde Mayes (born 1953), American professional basketball player
Colin Mayes (born 1948), Canadian politician
Derrick Mayes (born 1974), American football player
Frances Mayes (born 1940), American university professor, poet, memoirist, essayist, and novelist
Ian Mayes, British journalist and editor
Jeff Mayes (born 1971), American politician
Joel B. Mayes (died 1891), Chief of the Cherokee Nation
Johnny Mayes (born 1947), Australian rugby league player
Pete Mayes (1938–2008), American blues singer, guitarist and songwriter
Richard Mayes (1922–2006), English stage and television actor
Robert Burns Mayes (1867–1921), justice of the Supreme Court of Mississippi
Ron Mayes (born 1954), American educator and author
Rueben Mayes (born 1963), Canadian football player
Rufus Mayes (1947–1990), American football player
Samuel Houston Mayes (1845–1927), Chief of the Cherokee Nation from 1895 to 1899
Sean Mayes (1949–1995), English rock musician and author
Wendell Wise Mayes Jr. (1924–2021), American radio and cable television executive
William Mayes Jr., prominent pirate, proprietor of White Horse Tavern (Rhode Island)
William Edward Mayes (1861–1952), English painter
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